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Nat Rev Genet. 2011 May;12(5):357-62. doi: 10.1038/nrg2983. Epub 2011 Mar 22.

Heart failure: advances through genomics.

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  • 1The Heart Failure Research Center, Room K2-120, Academic Medical Center (AMC), Meibergdreef 15, 1105AZ Amsterdam, The Netherlands.


Heart failure is an increasingly prevalent and highly lethal disease that is most often caused by underlying pathologies, such as myocardial infarction or hypertension, but it can also be the result of a single gene mutation. Comprehensive genetic and genomic approaches are starting to disentangle the diverse molecular underpinnings of both forms of the disease and promise to yield much-needed novel diagnostic and therapeutic options for specific subtypes of heart failure.

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