Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Cell Mol Life Sci. 2011 Jun;68(11):1871-81. doi: 10.1007/s00018-011-0663-0. Epub 2011 Mar 10.

Matrix control of scarring.

Author information

  • 1Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA.

Abstract

Repair of wounds usually results in restoration of organ function, even if suboptimal. However, in a minority of situations, the healing process leads to significant scarring that hampers homeostasis and leaves the tissue compromised. This scar is characterized by an excess of matrix deposition that remains poorly organized and weakened. While we know much of the early stages of the repair process, the transition to wound resolution that limits scar formation is poorly understood. This is particularly true of the inducers of scar formation. Here, we present a hypothesis that it is the matrix itself that is a primary driver of scar, rather than being simply the result of other cellular dysregulations.

PMID:
21390544
[PubMed - indexed for MEDLINE]
PMCID:
PMC3764457
Free PMC Article

Images from this publication.See all images (3)Free text

Fig. 1
Fig. 2
Fig. 3
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Springer Icon for PubMed Central
    Loading ...
    Write to the Help Desk