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Mol Reprod Dev. 2011 Mar;78(3):151-60. doi: 10.1002/mrd.21289. Epub 2011 Feb 17.

Extrinsic and intrinsic control of germ cell proliferation in Caenorhabditis elegans.

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  • 1Department of Genetics, Yale University, New Haven, CT 06520, USA.

Abstract

The germ cells of Caenorhabditis elegans serve as a useful model to study the balance between proliferation and differentiation within the context of development and changing environmental signals experienced by the animal. Germ cells adjacent to a stem cell niche in the distal region of the gonad retain the capacity to divide during adulthood, making them unique from other cells in the organism. We will highlight recent advances in our understanding of mechanisms that control proliferation, as well as the signaling pathways involved in promoting mitosis at the expense of differentiation.

Copyright © 2011 Wiley-Liss, Inc.

PMID:
21337453
[PubMed - indexed for MEDLINE]
PMCID:
PMC3375679
Free PMC Article
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