Format

Send to:

Choose Destination
See comment in PubMed Commons below
Behav Genet. 2011 Jan;41(1):120-4. doi: 10.1007/s10519-011-9443-8. Epub 2011 Jan 13.

An application of the elastic net for an endophenotype analysis.

Author information

  • 1Yale University, New Haven, CT, USA.

Abstract

We provide an illustration of an application of the elastic net to a large number of common genetic variants in the context of the search for the genetic bases of an endophenotype conceivably related to individual differences in learning. GABA concentration in the occipital cortex, a critical area for reading, was obtained in a group (n = 76) of children aged 6-10 years. Two extreme groups, high and low, were selected for genotyping with the 650Y Illumina array chip (Ilmn650Y). An elastic net approach was applied to the resulting SNP dataset; 100 SNPs were identified for each chromosome as "interesting" based on having the highest absolute value coefficients. The analyses highlighted chromosomes 15 and 20, which contained 55 candidate genes. The STRING partner analyses of the associated proteins pointed to a number of related genes, most notably, GABA and NTRK receptors.

PMID:
21229297
[PubMed - indexed for MEDLINE]
PMCID:
PMC3613288
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer Icon for PubMed Central
    Loading ...
    Write to the Help Desk