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Cancer Immunol Immunother. 2011 Mar;60(3):413-8. doi: 10.1007/s00262-010-0944-8. Epub 2010 Nov 23.

Spontaneous and therapy-induced immunity to pluripotency genes in humans: clinical implications, opportunities and challenges.

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  • 1Section of Hematology, Yale University, New Haven, CT 06510, USA.


Recent studies have suggested that the core pathways regulating pluripotency in embryonal stem cells bear considerable overlap with oncogenesis. Here, we discuss recent insights into the capacity of the human immune system to target some of the key pluripotency-associated genes. Immunity to these genes is also induced in humans in the context of chemotherapy-induced cell death in patients with germ cell tumors. Immunologic targeting of pathways associated with stemness has implications for both immune regulation of tumor growth as well as emerging regenerative therapies with embryonal stem cells.

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