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Arch Neurol. 2010 Sep;67(9):1102-8. doi: 10.1001/archneurol.2010.197.

Elevated intrathecal myelin oligodendrocyte glycoprotein antibodies in multiple sclerosis.

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  • 1Department of Neurology, Washington University, St Louis, MO 63110, USA.

Abstract

OBJECTIVE:

To evaluate antibodies to myelin oligodendrocyte glycoprotein (MOG) in the serum and cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS) and control individuals.

DESIGN:

Prospective case-control series.

SETTING:

Academic referral center.

PATIENTS:

Twenty-six controls with noninflammatory neurologic disease and 35 patients with MS donated serum and CSF for recombinant MOG (rMOG) antibody determination.

MAIN OUTCOME MEASURES:

Serum and CSF rMOG antibody and albumin levels were used to calculate an rMOG index. Clinical disability, CSF markers, and magnetic resonance metrics were correlated with the rMOG index.

RESULTS:

The rMOG index was elevated in MS patients compared with controls (P = .01). Patients with progressive MS exhibited elevated rMOG indexes compared with patients with relapsing-remitting MS (P = .04). The rMOG index was inferior to the IgG index in differentiating MS patients from controls. However, 7 of 16 patients with MS who had normal immunoglobulin G indexes had an elevated rMOG index. The rMOG index did not correlate with clinical disability, other CSF markers, or radiographic outcome measures.

CONCLUSIONS:

The rMOG index, a marker of intrathecal MOG antibody production, may provide complementary information to routine CSF testing in the diagnosis of MS. Furthermore, intrathecal anti-MOG antibody production may be more pronounced in progressive than in relapsing forms of MS.

PMID:
20837855
[PubMed - indexed for MEDLINE]
PMCID:
PMC3051403
Free PMC Article
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