Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Child Adolesc Psychopharmacol. 2010 Aug;20(4):237-47. doi: 10.1089/cap.2009.0118.

Neurobiological substrates of Tourette's disorder.

Author information

  • 1Child Study Center, Yale University, New Haven, Connecticut 06520-7900, USA. james.leckman@yale.edu

Abstract

OBJECTIVE:

This article reviews the available scientific literature concerning the neurobiological substrates of Tourette's disorder (TD).

METHODS:

The electronic databases of PubMed, ScienceDirect, and PsycINFO were searched for relevant studies using relevant search terms.

RESULTS:

Neuropathological as well as structural and functional neuroimaging studies of TD implicate not only the sensorimotor corticostriatal circuit, but also the limbic and associative circuits as well. Preliminary evidence also points to abnormalities in the frontoparietal network that is thought to maintain adaptive online control. Evidence supporting abnormalities in dopaminergic and noradrenergic neurotransmission remains strong, although the precise mechanisms remain the subject of speculation.

CONCLUSION:

Structural and functional abnormalities in multiple parallel corticostriatal circuits may underlie the behavioral manifestations of TD and related neuropsychiatric disorders over the course of development. Further longitudinal research is needed to elucidate these neurobiological substrates.

PMID:
20807062
[PubMed - indexed for MEDLINE]
PMCID:
PMC2958453
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Mary Ann Liebert, Inc. Icon for PubMed Central
    Loading ...
    Write to the Help Desk