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J Neuroimmunol. 2010 Sep 14;226(1-2):192-3. doi: 10.1016/j.jneuroim.2010.06.016. Epub 2010 Jul 23.

A unique antibody gene signature is prevalent in the central nervous system of patients with multiple sclerosis.

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  • 1Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.


B cells isolated from the CSF of patients with multiple sclerosis (MS) have a unique accumulation of somatic hypermutation within the B cell receptor, termed the antibody gene signature (AGS). The focus of this study was to investigate whether the AGS could also be detected in MS brain tissue. Genetic analysis of B cells isolated from post-mortem CNS tissue samples from four MS brains demonstrated that signature enriched B cells are present at the site of tissue injury as well as in the circulating CSF.

Copyright © 2010 Elsevier B.V. All rights reserved.

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