Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm

Nat Genet. 2010 Aug;42(8):692-7. doi: 10.1038/ng.622. Epub 2010 Jul 11.

Abstract

We performed a genome-wide association study on 1,292 individuals with abdominal aortic aneurysms (AAAs) and 30,503 controls from Iceland and The Netherlands, with a follow-up of top markers in up to 3,267 individuals with AAAs and 7,451 controls. The A allele of rs7025486 on 9q33 was found to associate with AAA, with an odds ratio (OR) of 1.21 and P = 4.6 x 10(-10). In tests for association with other vascular diseases, we found that rs7025486[A] is associated with early onset myocardial infarction (OR = 1.18, P = 3.1 x 10(-5)), peripheral arterial disease (OR = 1.14, P = 3.9 x 10(-5)) and pulmonary embolism (OR = 1.20, P = 0.00030), but not with intracranial aneurysm or ischemic stroke. No association was observed between rs7025486[A] and common risk factors for arterial and venous diseases-that is, smoking, lipid levels, obesity, type 2 diabetes and hypertension. Rs7025486 is located within DAB2IP, which encodes an inhibitor of cell growth and survival.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Aortic Aneurysm, Abdominal / complications
  • Aortic Aneurysm, Abdominal / genetics*
  • Aortic Aneurysm, Abdominal / mortality
  • Base Sequence
  • Disease Susceptibility / complications
  • Genome-Wide Association Study
  • Humans
  • Hypertension / complications
  • Hypertension / genetics
  • Iceland
  • Myocardial Infarction / complications
  • Myocardial Infarction / genetics
  • Netherlands
  • Odds Ratio
  • Risk Factors
  • ras GTPase-Activating Proteins

Substances

  • DAB2IP protein, human
  • ras GTPase-Activating Proteins