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Mol Cell. 2010 Jul 9;39(1):8-24. doi: 10.1016/j.molcel.2010.06.017.

The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets.

Author information

  • 1Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.

Abstract

The abundant nuclear enzyme PARP-1, a multifunctional regulator of chromatin structure, transcription, and genomic integrity, plays key roles in a wide variety of processes in the nucleus. Recent studies have begun to connect the molecular functions of PARP-1 to specific physiological and pathological outcomes, many of which can be altered by an expanding array of chemical inhibitors of PARP enzymatic activity.

2010 Elsevier Inc. All rights reserved.

PMID:
20603072
[PubMed - indexed for MEDLINE]
PMCID:
PMC2923840
Free PMC Article

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