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Nat Methods. 2010 Aug;7(8):623-6. doi: 10.1038/nmeth.1473. Epub 2010 Jun 20.

Rationally improving LOV domain-based photoswitches.

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  • 1Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois, USA.

Abstract

Genetically encoded protein photosensors are promising tools for engineering optical control of cellular behavior; we are only beginning to understand how to couple these light detectors to effectors of choice. Here we report a method that increases the dynamic range of an artificial photoswitch based on the LOV2 domain of Avena sativa phototropin 1 (AsLOV2). This approach can potentially be used to improve many AsLOV2-based photoswitches.

Comment in

  • Hold me tightly LOV. [Nat Methods. 2010]
PMID:
20562867
[PubMed - indexed for MEDLINE]
PMCID:
PMC2914111
Free PMC Article

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