Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Leukoc Biol. 2010 Dec;88(6):1099-107. doi: 10.1189/jlb.0310183. Epub 2010 May 21.

How specificity for self-peptides shapes the development and function of regulatory T cells.

Author information

  • 1The Wistar Institute, Philadelphia, PA 19104, USA.

Abstract

The cataclysmic disease that develops in mice and humans lacking CD4+ T cells expressing the transcription factor Foxp3 has provided abundant evidence that Foxp3+CD4+ Tregs are required to suppress a latent autoreactivity of the immune system. There is also evidence for the existence of tissue-specific Tregs that can act to suppress regional autoimmune responses, suggesting that Tregs exert their effects, in part, through responding to self-peptides. However, how the immune system generates a repertoire of Tregs that is designed to recognize and direct regulatory function to self-peptides is incompletely understood. This review describes studies aimed at determining how T cell recognition of self-peptide(s) directs Treg formation in the thymus, including discussion of a modified "avidity" model of thymocyte development. Studies aimed at determining how TCR specificity contributes to the ability of Tregs to suppress autoimmune diseases are also discussed.

PMID:
20495071
[PubMed - indexed for MEDLINE]
PMCID:
PMC2996893
Free PMC Article

Images from this publication.See all images (3)Free text

Figure 1.
Figure 2.
Figure 3.
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk