Format

Send to:

Choose Destination
See comment in PubMed Commons below
Magn Reson Imaging. 2010 Oct;28(8):1051-7. doi: 10.1016/j.mri.2010.03.021. Epub 2010 Apr 21.

Functional connectivity between task-positive and task-negative brain areas and its relation to working memory performance.

Author information

  • 1Department of Diagnostic Radiology, Yale School of Medicine, New Haven, CT 06511, USA. michelle.hampson@yale.edu

Abstract

Functional brain imaging studies have identified a set of brain areas typically activated during cognitive tasks (task-positive brain areas) and another set of brain areas typically deactivated during cognitive tasks (task-negative brain areas). Negative correlations, or anticorrelations, between task-positive and task-negative brain areas have been reported at rest. Furthermore, the strength of these anticorrelations appears to be related to cognitive function. However, studies examining anticorrelations have typically employed global regression or similar analysis steps that force anticorrelated relationships to exist between brain areas. Therefore the validity of these findings has been questioned. Here we examine anticorrelations between a task-negative region in the medial frontal gyrus/anterior cingulate cortex and dorsolateral prefrontal cortex, a classic task-positive area, using an analysis that does not include global regression. Instead, we control for whole-brain correlations in the group-level analysis. Using this approach, we demonstrate that the strength of the functional connection between the medial frontal cortex and the dorsolateral prefrontal cortex is related to cognitive function and that this relationship is not an artifact of global regression.

Copyright © 2010 Elsevier Inc. All rights reserved.

PMID:
20409665
[PubMed - indexed for MEDLINE]
PMCID:
PMC2936669
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk