Send to:

Choose Destination
See comment in PubMed Commons below
Nat Rev Clin Oncol. 2010 Jul;7(7):415-20. doi: 10.1038/nrclinonc.2010.40. Epub 2010 Apr 20.

Alemtuzumab as a bridge to allogeneic SCT in atypical hemophagocytic lymphohistiocytosis.

Author information

  • 1Section of Hematology, Yale Cancer Center and Smilow Cancer Hospital at Yale-New Haven, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.



A 39-year-old woman with no relevant medical or family history was admitted to hospital with episodic fever, which persisted despite antibiotic therapy. Other notable findings at admission were splenomegaly, pancytopenia, hyponatremia, elevated levels of liver enzymes, hyperferritinemia and hypofibrinogenemia.


Physical examination, laboratory tests, rheumatic marker serology, pathogen detection assays, complete blood counts, measurement of levels of ferritin, fibrinogen, triglycerides and soluble CD25, natural killer cell functional studies, PRF1 mutation analysis, renal biopsy, bone marrow biopsy, CT imaging of the chest and abdomen.


Idiopathic, atypical hemophagocytic lymphohistiocytosis.


Initial treatment with antibiotics was followed by immunosuppressive therapy (including intravenous immunoglobulin, ciclosporin, infliximab, corticosteroids and etoposide). Remission was achieved by treatment with the anti-CD52 monoclonal antibody, alemtuzumab, after which allogeneic stem-cell transplantation (with reduced-intensity conditioning treatment and graft-versus-host disease prophylaxis) resulted in a definitive cure.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Write to the Help Desk