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Semin Hematol. 2010 Apr;47 Suppl 1:S8-10. doi: 10.1053/j.seminhematol.2010.01.012.

Enhancing existing approaches to peripheral T-cell lymphoma.

Author information

  • 1Yale Cancer Center, New Haven, CT, USA. francine.foss@yale.edu

Abstract

The National Comprehensive Cancer Network (NCCN) practice guidelines for peripheral T-cell lymphoma (PTCL) accentuate the lack of standard treatment options for this disease. Outcomes with conventional therapies, many of which are borrowed from B-cell lymphoma, are poor. Strategies to enhance existing approaches include creating a new platform for first-line therapy and adding novel agents, such as denileukin diftitox, to existing chemotherapy platforms. Furthermore, to improve outcomes, patients must reach transplant through effective first-line therapies. Additionally, treatment should be individualized based on histopathologic subtype, as all PTCL patients will not respond to the same treatment regimen.

Copyright 2010. Published by Elsevier Inc.

PMID:
20359584
[PubMed - indexed for MEDLINE]
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