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Atherosclerosis. 2010 Jun;210(2):671-3. doi: 10.1016/j.atherosclerosis.2009.12.034. Epub 2010 Jan 4.

Higher fibrinogen levels predict progression of coronary artery calcification in adults with type 1 diabetes.

Author information

  • 1Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Health Sciences Center, Aurora CO 80045, USA. ticianacr@yahoo.com.br

Abstract

AIM:

To determine whether fibrinogen levels predict independently progression of coronary artery calcification (CAC) in adults with type 1 diabetes.

METHODS:

Data from a prospective cohort--the Coronary Artery Calcification in Type 1 Diabetes Study--were evaluated. Fibrinogen levels at baseline were separated into quartiles. CAC was measured twice and averaged at baseline and at follow-up 2.4+/-0.4 years later. CAC progressors were defined as participants whose square-root transformed CAC volume increased by >or=2.5 mm3 or development of clinical coronary artery disease during the follow-up period.

RESULTS:

Fibrinogen levels were higher in progressors than in non-progressors (276+/-61 mg/dl versus 259+/-61 mg/dl, p=0.0003). CAC progression, adjusted for known cardiovascular risk factors, increased in the highest quartile.

CONCLUSIONS:

Higher fibrinogen levels predict CAC progression in type 1 diabetes subjects, independent of standard cardiovascular risk factors.

Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.

PMID:
20079495
[PubMed - indexed for MEDLINE]
PMCID:
PMC2896570
Free PMC Article

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