Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Atherosclerosis. 2010 Jun;210(2):671-3. doi: 10.1016/j.atherosclerosis.2009.12.034. Epub 2010 Jan 4.

Higher fibrinogen levels predict progression of coronary artery calcification in adults with type 1 diabetes.

Author information

  • 1Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Health Sciences Center, Aurora CO 80045, USA. ticianacr@yahoo.com.br



To determine whether fibrinogen levels predict independently progression of coronary artery calcification (CAC) in adults with type 1 diabetes.


Data from a prospective cohort--the Coronary Artery Calcification in Type 1 Diabetes Study--were evaluated. Fibrinogen levels at baseline were separated into quartiles. CAC was measured twice and averaged at baseline and at follow-up 2.4+/-0.4 years later. CAC progressors were defined as participants whose square-root transformed CAC volume increased by >or=2.5 mm3 or development of clinical coronary artery disease during the follow-up period.


Fibrinogen levels were higher in progressors than in non-progressors (276+/-61 mg/dl versus 259+/-61 mg/dl, p=0.0003). CAC progression, adjusted for known cardiovascular risk factors, increased in the highest quartile.


Higher fibrinogen levels predict CAC progression in type 1 diabetes subjects, independent of standard cardiovascular risk factors.

Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.

[PubMed - indexed for MEDLINE]
Free PMC Article

Images from this publication.See all images (1)Free text

Figure 1
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk