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Rheumatol Int. 2012 Jan;32(1):249-51. doi: 10.1007/s00296-009-1322-8. Epub 2009 Dec 18.

Etanercept and anakinra can prolong febrile episodes in patients with hyperimmunoglobulin D and periodic fever syndrome.

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  • 1Royal Victoria Hospital, Belfast, Northern Ireland, UK. hiba.shendi@belfasttrust.hscni.net


Hyperimmunoglobulin D and periodic fever syndrome (HIDS) is a rare, hereditary autoinflammatory condition, characterized by recurrent inflammatory episodes. There is no proven treatment for HIDS, but various drugs including, non-steroidal anti-inflammatory drugs, colchicine, steroids, statins and thalidomide have all been tried. Recently, some patients have demonstrated a good clinical response to either etanercept or anakinra. We report a case of a 10-year-old girl who experienced prolonged and severe inflammatory attacks, when she was treated with etanercept, and later with anakinra.

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