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The role of the adenosinergic system in lung fibrosis.
Pharmacol Res. 2013 Oct;76:182-9. doi: 10.1016/j.phrs.2013.08.004. Epub 2013 Aug 28.
Pharmacol Res. 2013.
PMID: 23994158
Review.
Triazoloquinazolinediones as novel high affinity ligands for the benzodiazepine site of GABA(A) receptors.
Nilsson J, Gidlöf R, Nielsen EØ, Liljefors T, Nielsen M, Sterner O.
Nilsson J, et al.
Bioorg Med Chem. 2011 Jan 1;19(1):111-21. doi: 10.1016/j.bmc.2010.11.050. Epub 2010 Nov 25.
Bioorg Med Chem. 2011.
PMID: 21163663
Based on a pharmacophore model of the benzodiazepine-binding site of GABA(A) receptors, a series of 2-aryl-2,6-dihydro[1,2,4]triazolo[4,3-c]quinazoline-3,5-diones (structure type I) were designed, synthesized, and identified as high-affinity ligands of the binding s …
Based on a pharmacophore model of the benzodiazepine-binding site of GABA(A) receptors, a series of 2-aryl-2,6-dihydro[1,2,4]triazolo …
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A3 adenosine receptor antagonists delay irreversible synaptic failure caused by oxygen and glucose deprivation in the rat CA1 hippocampus in vitro.
Pugliese AM, Coppi E, Spalluto G, Corradetti R, Pedata F.
Pugliese AM, et al.
Br J Pharmacol. 2006 Mar;147(5):524-32. doi: 10.1038/sj.bjp.0706646.
Br J Pharmacol. 2006.
PMID: 16415905
Free PMC article.
In all, 7 min of OGD evoked tissue anoxic depolarisation (AD, peak at approximately 7 min from OGD start, n=20) and were invariably followed by irreversible loss of electrically evoked field epsps (fepsps, n=42).The selective adenosine A3 antagonists 3-propyl-6-ethyl-5[(ethylthio …
In all, 7 min of OGD evoked tissue anoxic depolarisation (AD, peak at approximately 7 min from OGD start, n=20) and were invariably followed …
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Activation of A(3) receptors by endogenous adenosine inhibits synaptic transmission during hypoxia in rat cortical neurons.
Hentschel S, Lewerenz A, Nieber K.
Hentschel S, et al.
Restor Neurol Neurosci. 2003;21(1-2):55-63.
Restor Neurol Neurosci. 2003.
PMID: 12808203
Hypoxic inhibition induced after A(1) receptor blockade with 1,3-dipropyl-8-cyclopentylxanthine (DPCPX) in the presence of NBTG was completely reversed by the A(3) antagonist 9-chloro-2-(2-furanyl)-5-[(phenylacetyl)amino]-1,2,4-triazolo[1,5-c]quinazoline (MRS 1220), …
Hypoxic inhibition induced after A(1) receptor blockade with 1,3-dipropyl-8-cyclopentylxanthine (DPCPX) in the presence of NBTG was complete …
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