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Year Number of Results
1947 4
1948 4
1950 1
1951 1
1952 7
1954 3
1955 3
1956 2
1958 1
1959 2
1960 1
1961 3
1962 1
1963 2
1964 1
1965 2
1966 2
1968 3
1970 1
1971 3
1972 2
1973 1
1975 2
1976 8
1977 4
1978 4
1979 15
1980 21
1981 26
1982 43
1983 46
1984 35
1985 50
1986 47
1987 40
1988 37
1989 36
1990 44
1991 43
1992 37
1993 36
1994 41
1995 33
1996 23
1997 30
1998 31
1999 32
2000 25
2001 35
2002 27
2003 22
2004 18
2005 29
2006 16
2007 16
2008 13
2009 9
2010 13
2011 6
2012 11
2013 7
2014 7
2015 2
2016 6
2017 11
2018 8
2019 1
2020 10
2021 7
2022 3
2023 4
2024 0

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1,098 results

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Page 1
Genetic toxicity of 2-acetylaminofluorene, 2-aminofluorene and some of their metabolites and model metabolites.
Heflich RH, Neft RE. Heflich RH, et al. Mutat Res. 1994 Oct;318(2):73-114. doi: 10.1016/0165-1110(94)90025-6. Mutat Res. 1994. PMID: 7521935 Review.
2-Acetylaminofluorene and 2-aminofluorene are among the most intensively studied of all chemical mutagens and carcinogens. ...The reactive derivatives are active in virtually all systems, while 2-acetylaminofluorene and 2-aminofluorene are active in mo …
2-Acetylaminofluorene and 2-aminofluorene are among the most intensively studied of all chemical mutagens and carcinogens. ... …
Formation of N-2-fluorenylhydroxylamine adducts of DNA in vivo and in vitro and some of their properties.
Kriek E, Westra JG. Kriek E, et al. Natl Cancer Inst Monogr. 1981 Dec;(58):139-42. Natl Cancer Inst Monogr. 1981. PMID: 7341970
The major 2-fluorenylamine-DNA derivative formed in vivo in rat liver after application of N-2-flourencylacetamide is N-(deoxyguanosin-8-yl)-2-fluorenylamine. ...
The major 2-fluorenylamine-DNA derivative formed in vivo in rat liver after application of N-2-flourencylacetamide is N-(deoxy …
Metabolism of 2-nitrofluorene, 2-aminofluorene and 2-acylaminofluorenes in rat and dog and the role of intestinal bacteria.
Ueda O, Kitamura S, Kubo R, Yano Y, Kanzaki Y, Fujimoto T, Tatsumi K, Ohta S. Ueda O, et al. Xenobiotica. 2001 Jan;31(1):33-49. doi: 10.1080/00498250010031647. Xenobiotica. 2001. PMID: 11339231
The in vivo metabolism of 2-nitrofluorene (NF), an environmental pollutant, and 2-aminofluorene (AF) and its acylated derivatives, 2-formylaminofluorene (FAF) and 2-acetylaminofluorene (AAF), was examined in rat and dog. 2. 7-Hydroxy-2-nitrofluorene, 5-hydroxy-2-nit …
The in vivo metabolism of 2-nitrofluorene (NF), an environmental pollutant, and 2-aminofluorene (AF) and its acylated derivati …
DNA modification by chemical carcinogens.
Jeffrey AM. Jeffrey AM. Pharmacol Ther. 1985;28(2):237-72. doi: 10.1016/0163-7258(85)90013-0. Pharmacol Ther. 1985. PMID: 3936066 Review.
Metabolic and genotoxic interactions of 2-aminofluorene and 2,4-diaminotoluene.
Pan YH, Reed GA. Pan YH, et al. Toxicol Lett. 1997 Mar 14;91(1):73-82. doi: 10.1016/s0378-4274(97)03871-x. Toxicol Lett. 1997. PMID: 9096289
We have reported previously that the rodent carcinogen 2,4-diaminotoluene (2,4-DAT) is not activated as a mutagen to the standard Ames S. typhimurium tester strains when oxidized by prostaglandin H synthase (PHS). 2,4-DAT does, however, enhance the bacterial mutagenicity of the p …
We have reported previously that the rodent carcinogen 2,4-diaminotoluene (2,4-DAT) is not activated as a mutagen to the standard Ames S. ty …
The oxidation of 2-aminofluorene by prostaglandin endoperoxide synthetase. Comparison with other peroxidases.
Boyd JA, Harvan DJ, Eling TE. Boyd JA, et al. J Biol Chem. 1983 Jul 10;258(13):8246-54. J Biol Chem. 1983. PMID: 6408086 Free article.
We have examined the prostaglandin endoperoxide synthetase-dependent metabolism of the arylamine carcinogen 2-aminofluorene (2-AF). Ram seminal vesicle microsomes fortified with arachidonic acid metabolize 2-AF to products covalently bound to microsomal macromolecul …
We have examined the prostaglandin endoperoxide synthetase-dependent metabolism of the arylamine carcinogen 2-aminofluorene (2 …
Role of Human N-Acetyltransferase 2 Genetic Polymorphism on Aromatic Amine Carcinogen-Induced DNA Damage and Mutagenicity in a Chinese Hamster Ovary Cell Mutation Assay.
Baldauf KJ, Salazar-González RA, Doll MA, Pierce WM Jr, States JC, Hein DW. Baldauf KJ, et al. Environ Mol Mutagen. 2020 Feb;61(2):235-245. doi: 10.1002/em.22331. Epub 2019 Sep 30. Environ Mol Mutagen. 2020. PMID: 31490564 Free PMC article.
Carcinogenic aromatic amines such as 4-aminobiphenyl (ABP) and 2-aminofluorene (AF) require metabolic activation to form electrophilic intermediates that mutate DNA leading to carcinogenesis. ...DNA damage also was quantified by gammaH2AX in-cell western assays and …
Carcinogenic aromatic amines such as 4-aminobiphenyl (ABP) and 2-aminofluorene (AF) require metabolic activation to form elect …
Lack of carcinogenicity of 2-aminofluorene, its glucuronide and the glucuronide of N-hydroxy-2-acetylaminofluorene in heterotopic bladder of the rat.
Wang CY, Imaida K, Zukowski K, Lee MS. Wang CY, et al. Cancer Lett. 1991 Feb;56(2):153-7. doi: 10.1016/0304-3835(91)90090-5. Cancer Lett. 1991. PMID: 1998944
The role of 2-aminofluorene and its N-glucuronide and the O-glucuronide of N-hydroxy-2-acetylaminofluorene in the bladder carcinogenesis by 2-aminofluorene were investigated. ...The O-glucuronide was not carcinogenic even when it was administered in a …
The role of 2-aminofluorene and its N-glucuronide and the O-glucuronide of N-hydroxy-2-acetylaminofluorene in the bladder carc …
Metabolism of 2-acetylaminofluorene in the Chinese hamster ovary cell mutation assay.
Heflich RH, Djurić Z, Zhuo Z, Fullerton NF, Casciano DA, Beland FA. Heflich RH, et al. Environ Mol Mutagen. 1988;11(2):167-81. doi: 10.1002/em.2850110203. Environ Mol Mutagen. 1988. PMID: 3345736
Chinese hamster ovary (CHO) cells were exposed to 2-acetylaminofluorene (2-AAF) and 2-aminofluorene (2-AF), and several of their N-oxidized metabolites in order to study the mechanisms by which arylamides and arylamines produce mutations in mammalian cells. ...
Chinese hamster ovary (CHO) cells were exposed to 2-acetylaminofluorene (2-AAF) and 2-aminofluorene (2-AF), and several of the …
1,098 results