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The following terms were ignored: [1-, ]
The following terms were not found in PubMed: -5-methoxy-2-methyl-indol-3-yl, -N-cyclopropyl-acetamide
Page 1
Green synthesis, structure optimization and biological evalution of Rhopaladins' analog 2-styryl-5-oxopyrrolidine-2- carboxamide RPDPRH on CaSki cells.
Ke LN, Kong LQ, Zhu XL, Wu FX, Chen QH, Li B, Dong Y, Wang HM, Zeng XH. Ke LN, et al. Front Chem. 2022 Aug 30;10:975559. doi: 10.3389/fchem.2022.975559. eCollection 2022. Front Chem. 2022. PMID: 36110131 Free PMC article.
Finally, we confirmed that compared with the previous compound (E)-N-(tert-butyl)-2-(4-chlorobenzoyl)-4-(4-fluorobenzylidene)-1-isopropyl-5-oxopyrrolidine-2-carboxamide (RPDPB), RPDPRH could better inhibit proliferation, induce apoptosis, and down-regulate HP …
Finally, we confirmed that compared with the previous compound (E)-N-(tert-butyl)-2-(4-chlorobenzoyl)-4-(4-fluorobenzyl …
Design, synthesis and evaluation of benzofuran-acetamide scaffold as potential anticonvulsant agent.
Shakya AK, Kamal M, Balaramnavar VM, Bardaweel SK, Naik RR, Saxena AK, Siddiqui HH. Shakya AK, et al. Acta Pharm. 2016 Sep 1;66(3):353-72. doi: 10.1515/acph-2016-0023. Acta Pharm. 2016. PMID: 27383885 Free article.
The majority of compounds exhibited anticonvulsant activity at a dose of 30 mg kg-1 body mass during 0.5-4 h, indicating their ability to prevent seizure spread at low doses. Relative to phenytoin, [N-(2-(4-chlorobenzoyl)benzofuran-3-yl)-2-(cyclohexyl( methyl …
The majority of compounds exhibited anticonvulsant activity at a dose of 30 mg kg-1 body mass during 0.5-4 h, indicating their ability to pr …
Efficient synthesis of [6-chloro-2-(4-chlorobenzoyl)-1H-indol-3-yl]-acetic acid, a novel COX-2 inhibitor.
Caron S, Vazquez E, Stevens RW, Nakao K, Koike H, Murata Y. Caron S, et al. J Org Chem. 2003 May 16;68(10):4104-7. doi: 10.1021/jo034274r. J Org Chem. 2003. PMID: 12737602
The synthesis of 6-chloro-2-(4-chlorobenzoyl)-1H-indol-3-ylacetic acid (1), a selective cyclooxygenase 2 (COX-2) inhibitor, is described. ...
The synthesis of 6-chloro-2-(4-chlorobenzoyl)-1H-indol-3-ylacetic acid (1), a selective cyclooxygenase 2 (COX-2) inhibi …
Four related esters: two 4-(aroylhydrazinyl)-3-nitrobenzoates and two 3-aryl-1,2,4-benzotriazine-6-carboxylates.
Cortés E, Abonía R, Cobo J, Glidewell C. Cortés E, et al. Acta Crystallogr C. 2013 Jul;69(Pt 7):754-60. doi: 10.1107/S0108270113013590. Epub 2013 Jun 8. Acta Crystallogr C. 2013. PMID: 23832037
The molecules of both methyl 4-[2-(4-chlorobenzoyl)hydrazinyl]-3-nitrobenzoate, C15H12ClN3O5, (I), and methyl 4-[2-(2-fluorobenzoyl)hydrazinyl]-3-nitrobenzoate, C15H12FN3O5, (II), contain an intramolecular N-H...O hydrogen bond, and both show electronic polar …
The molecules of both methyl 4-[2-(4-chlorobenzoyl)hydrazinyl]-3-nitrobenzoate, C15H12ClN3O5, (I), and methyl 4-[2-(2-f …
Synthetic Inhibitors of Snake Venom Enzymes: Thioesters Derived from 2-Sulfenyl Ethylacetate.
Henao Castañeda IC, Pereañez JA, Preciado LM. Henao Castañeda IC, et al. Pharmaceuticals (Basel). 2019 May 23;12(2):80. doi: 10.3390/ph12020080. Pharmaceuticals (Basel). 2019. PMID: 31126073 Free PMC article.
This work aimed to synthesize thioesters derived from 2-sulfenyl ethylacetate and to evaluate the inhibitory effects on two snake venom toxins. Ethyl 2-((4-chlorobenzoyl)thio)acetate (I), Ethyl 2-((3-nitrobenzoyl)thio)acetate (II) and Ethyl 2-((4-nitrobenzoyl …
This work aimed to synthesize thioesters derived from 2-sulfenyl ethylacetate and to evaluate the inhibitory effects on two snake venom toxi …
Design, syntheses, biological evaluation, and docking studies of 2-substituted 5-methylsulfonyl-1-phenyl-1H-indoles: potent and selective in vitro cyclooxygenase-2 inhibitors.
Cruz-López O, Díaz-Mochón JJ, Campos JM, Entrena A, Núñez MT, Labeaga L, Orjales A, Gallo MA, Espinosa A. Cruz-López O, et al. ChemMedChem. 2007 Jan;2(1):88-100. doi: 10.1002/cmdc.200600179. ChemMedChem. 2007. PMID: 17131462
According to docking studies, these molecules appear to bind the COX-2 binding site differently than indomethacin, with the insertion of the substituent at the 2-position in the hydrophobic pocket of the enzyme and the 1-position phenyl ring in the trifluoromethyl zone. Among the …
According to docking studies, these molecules appear to bind the COX-2 binding site differently than indomethacin, with the insertion of the …
Aroyl(aminoacyl)pyrroles, a new class of anticonvulsant agents.
Carson JR, Carmosin RJ, Pitis PM, Vaught JL, Almond HR, Stables JP, Wolf HH, Swinyard EA, White HS. Carson JR, et al. J Med Chem. 1997 May 23;40(11):1578-84. doi: 10.1021/jm9606655. J Med Chem. 1997. PMID: 9171868
These compounds were active in the mouse and rat maximal electroshock tests but not in the mouse metrazole test. The lead compound, RWJ-37868, 2-(4-chlorobenzoyl)-4-(1-piperidinyl-acetyl)-1,3,5-trimethylpyrrole++ + (4d), showed potency and therapeutic index c …
These compounds were active in the mouse and rat maximal electroshock tests but not in the mouse metrazole test. The lead compound, RWJ-3786 …
Synthesis and pharmacological investigations of some 4-hydroxycoumarin derivatives.
Manolov I, Danchev ND. Manolov I, et al. Arch Pharm (Weinheim). 2003 Apr;336(2):83-94. doi: 10.1002/ardp.200390010. Arch Pharm (Weinheim). 2003. PMID: 12761761
A comparative pharmacological study of the in vivo anticoagulant effects of the derivatives with respect to warfarin, showed that the compounds have anticoagulant activity. Compounds 4-hydroxy-3-[1-phenyl-2-(4'-chlorobenzoyl)ethyl]-2H-1-benzopyran-2-one 2b, 4 …
A comparative pharmacological study of the in vivo anticoagulant effects of the derivatives with respect to warfarin, showed that the compou …
15 results