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Synthesis and biological characterization of 1,4,5,6-tetrahydropyrimidine and 2-amino-3,4,5,6-tetrahydropyridine derivatives as selective m1 agonists.
J Med Chem. 1997 Apr 11;40(8):1230-46. doi: 10.1021/jm960467d.
J Med Chem. 1997.
PMID: 9111297
Investigation of the Possible Pharmacologically Active Forms of the Nicotinic Acetylcholine Receptor Agonist Anabaseine.
Andrud K, Xing H, Gabrielsen B, Bloom L, Mahnir V, Lee S, Green BT, Lindstrom J, Kem W.
Andrud K, et al.
Mar Drugs. 2019 Oct 29;17(11):614. doi: 10.3390/md17110614.
Mar Drugs. 2019.
PMID: 31671780
Free PMC article.
However, since they occur at equal concentrations near physiological pH, we employed another approach, preparing a stable analog of each form and examining its agonist activities and binding affinities at several vertebrate brain and neuromuscular nAChRs. Only 2-(3- …
However, since they occur at equal concentrations near physiological pH, we employed another approach, preparing a stable analog of each for …
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Effects of nucleus basalis lesions on the muscarinic and nicotinic modulation of [3H]acetylcholine release in the rat cerebral cortex.
Meyer EM, Arendash GW, Judkins JH, Ying L, Wade C, Kem WR.
Meyer EM, et al.
J Neurochem. 1987 Dec;49(6):1758-62. doi: 10.1111/j.1471-4159.1987.tb02433.x.
J Neurochem. 1987.
PMID: 3681294
Synaptosomal [3H]ACh release was not altered by nicotine or the nicotinic agonists anabaseine and 2-(3-pyridyl)-1,4,5,6-tetrahydropyrimidine. Nicotine (10-100 microM) did increase [3H]ACh release in control and lesioned hemi …
Synaptosomal [3H]ACh release was not altered by nicotine or the nicotinic agonists anabaseine and 2-(3-pyridyl)-1 …
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