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The following term was not found in PubMed: 2-cyclopropylethylthio
Page 1
Synthesis of (2-chloroquinolin-3-yl)-1,3,4-thiadiazole-2-carboxamides.
Aksenov AN, Krayushkin MM, Yarovenko VN. Aksenov AN, et al. Russ Chem Bull. 2021;70(6):1131-1134. doi: 10.1007/s11172-021-3194-3. Epub 2021 Jul 14. Russ Chem Bull. 2021. PMID: 34305379 Free PMC article.
(2-Chloroquinolin-3-yl)-1,3,4-thiadiazole-2-carboxamides were synthesized from hydrazones obtained via the reaction of 3-formyl-2-chloroquinoline with oxamic acid thiohydrazides....
(2-Chloroquinolin-3-yl)-1,3,4-thiadiazole-2-carboxamides were synthesized from hydrazones obtained …
2-Amino-1,3,4-thiadiazole as a potential scaffold for promising antimicrobial agents.
Serban G, Stanasel O, Serban E, Bota S. Serban G, et al. Drug Des Devel Ther. 2018 May 31;12:1545-1566. doi: 10.2147/DDDT.S155958. eCollection 2018. Drug Des Devel Ther. 2018. PMID: 29910602 Free PMC article. Review.
The aim of this review was to highlight the main antimicrobial properties exhibited by derivatives possessing 2-amino-1,3,4-thiadiazole moiety. Many of the reported 2-amino-1,3,4-thiadiazole derivatives can be …
The aim of this review was to highlight the main antimicrobial properties exhibited by derivatives possessing 2-amino-1,3 …
New 1,3,4-Thiadiazole Derivatives with Anticancer Activity.
Janowska S, Khylyuk D, Bielawska A, Szymanowska A, Gornowicz A, Bielawski K, Noworól J, Mandziuk S, Wujec M. Janowska S, et al. Molecules. 2022 Mar 10;27(6):1814. doi: 10.3390/molecules27061814. Molecules. 2022. PMID: 35335177 Free PMC article.
We designed and synthesized the 1,3,4-thiadiazole derivatives differing in the structure of the substituents in C2 and C5 positions. ...The results showed that in both breast cancer cell lines, the strongest anti-proliferative activity was exerted by …
We designed and synthesized the 1,3,4-thiadiazole derivatives differing in the structure of the substituents in …
A Novel Approach to the Synthesis of 1,3,4-Thiadiazole-2-amine Derivatives.
Kokovina TS, Gadomsky SY, Terentiev AA, Sanina NA. Kokovina TS, et al. Molecules. 2021 Aug 25;26(17):5159. doi: 10.3390/molecules26175159. Molecules. 2021. PMID: 34500593 Free PMC article.
The main purpose of the study was the development of a new method for synthesis of 1,3,4-thiadiazol-2-amine derivatives in a one-pot manner using the reaction between a thiosemicarbazide and carboxylic acid without toxic additives such as POCl(3) or SOCl(2). ...It w …
The main purpose of the study was the development of a new method for synthesis of 1,3,4-thiadiazol-2-amine derivatives in a one-pot …
1,3,4-Thiadiazolo (3,2-alpha) Pyrimidine-6-Carbonitrile Scaffold as PARP1 Inhibitors.
Kaviarasan L, Eldhose E, Krishnamurthy PT, Rajagopal K, Mohammed M, Prudviraj P, Byran G. Kaviarasan L, et al. Anticancer Agents Med Chem. 2021;21(15):2050-2065. doi: 10.2174/1871520621666201216095018. Anticancer Agents Med Chem. 2021. PMID: 33327923
OBJECTIVE: The objective of the study was to synthesize a series of 5-amino-7-(substituted aldehyde)-2[(naphthalene- 2-yloxy)methyl] -[1,3,4]thiadiazolo-[3,2-alpha]-pyrimidine-6- carbonitrile derivatives and evaluate their possible in vitro and in vivo antica …
OBJECTIVE: The objective of the study was to synthesize a series of 5-amino-7-(substituted aldehyde)-2[(naphthalene- 2-yloxy)m …
Novel 1,3,4-thiadiazole/oxadiazole-linked honokiol derivatives suppress cancer via inducing PI3K/Akt/mTOR-dependent autophagy.
Xu T, Tian W, Zhang Q, Liu J, Liu Z, Jin J, Guo Y, Bai LP. Xu T, et al. Bioorg Chem. 2021 Oct;115:105257. doi: 10.1016/j.bioorg.2021.105257. Epub 2021 Aug 10. Bioorg Chem. 2021. PMID: 34426156
Honokiol is a bioactive biphenolic component derived from Magnoliae officinalis Cortex (known as "Hou Po" in Chinese), a traditional Chinese herbal medicine. A series of novel 1,3,4-thiadiazole/oxadiazole-linked honokiol derivatives were synthesized an …
Honokiol is a bioactive biphenolic component derived from Magnoliae officinalis Cortex (known as "Hou Po" in Chinese), a traditional Chinese …
2-Amino-5-methyl-1,3,4-thiadiazole and 2-amino-5-ethyl-1,3,4-thiadiazole.
Lynch DE. Lynch DE. Acta Crystallogr C. 2001 Oct;57(Pt 10):1201-3. doi: 10.1107/s0108270101011817. Epub 2001 Oct 12. Acta Crystallogr C. 2001. PMID: 11600785
The structures of 2-amino-5-methyl-1,3,4-thiadiazole, C(3)H(5)N(3)S, and 2-amino-5-ethyl-1,3,4-thiadiazole, C(4)H(7)N(3)S, have been determined for comparison with unsubstituted 2-amino-1,3 …
The structures of 2-amino-5-methyl-1,3,4-thiadiazole, C(3)H(5)N(3)S, and 2-amino-5-ethyl-1, …
Synthesis of 1,2,3-triazole-1,3,4-thiadiazole hybrids as novel alpha-glucosidase inhibitors by in situ azidation/click assembly.
Kumar H, Dhameja M, Kurella S, Uma A, Gupta P. Kumar H, et al. Arch Pharm (Weinheim). 2023 Aug;356(8):e2300145. doi: 10.1002/ardp.202300145. Epub 2023 May 26. Arch Pharm (Weinheim). 2023. PMID: 37236165
alpha-Glucosidase inhibition is widely used in the oral management of diabetes mellitus (DM), a disease characterized by high blood sugar levels (hyperglycemia) and abnormal carbohydrate metabolism. In this respect, a series of 1,2,3-triazole-1,3,4- …
alpha-Glucosidase inhibition is widely used in the oral management of diabetes mellitus (DM), a disease characterized by high blood sugar le …
Dipotassium 1,3,4-thiadiazole-2,5-bis(thiolate) as a new S-donor for direct synthesis of symmetrical disulfides.
Soleiman-Beigi M, Alikarami M, Kohzadi H, Akbari Z. Soleiman-Beigi M, et al. Sci Rep. 2022 Sep 27;12(1):16149. doi: 10.1038/s41598-022-20642-5. Sci Rep. 2022. PMID: 36167798 Free PMC article.
In this research, a simple, efficient and novel protocol is eveloped for the direct synthesis of symmetrical disulfides using dipotassium 1,3,4-thiadiazole-2,5-bis(thiolate) as a new, low toxicity, inexpensive, stable solid and free of foul-smel …
In this research, a simple, efficient and novel protocol is eveloped for the direct synthesis of symmetrical disulfides using dipotassium …
Synthesis of novel 2-acetamide-5-phenylthio-1,3,4-thiadiazole-containing phenyl urea derivatives as potential VEGFR-2 inhibitors.
Toolabi M, Safari F, Ayati A, Fathi P, Moghimi S, Salarinejad S, Foroumadi R, Ketabforoosh SHME, Foroumadi A. Toolabi M, et al. Arch Pharm (Weinheim). 2022 Mar;355(3):e2100397. doi: 10.1002/ardp.202100397. Epub 2022 Jan 10. Arch Pharm (Weinheim). 2022. PMID: 35014090
A novel series of 2-acetamide-5-phenylthio-1,3,4-thiadiazol derivatives containing a phenyl urea warhead were synthesized and evaluated as antiproliferative agents. The cytotoxic activities of the newly synthesized compounds were evaluated toward three human cancer cell li …
A novel series of 2-acetamide-5-phenylthio-1,3,4-thiadiazol derivatives containing a phenyl urea warhead were synthesized and evaluat …
1,139 results