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The following term was not found in PubMed: 5-benzoxazocin-6-one
Page 1
Discovery of 2-[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptor beta agonist in clinical trials for the treatment of dyslipidemia.
Kelly MJ, Pietranico-Cole S, Larigan JD, Haynes NE, Reynolds CH, Scott N, Vermeulen J, Dvorozniak M, Conde-Knape K, Huang KS, So SS, Thakkar K, Qian Y, Banner B, Mennona F, Danzi S, Klein I, Taub R, Tilley J. Kelly MJ, et al. J Med Chem. 2014 May 22;57(10):3912-23. doi: 10.1021/jm4019299. Epub 2014 Apr 8. J Med Chem. 2014. PMID: 24712661
Fenoldopam.
[No authors listed] [No authors listed] 2020 Oct 19. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. 2020 Oct 19. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. PMID: 30000704 Free Books & Documents. Review.
rac-5-Diphenylacetyl-2,2,4-trimethyl-2,3,4,5-tetrahydro-1,5-benzothiazepine and rac-5-formyl-2,2,4-trimethyl-2,3,4,5-tetrahydro-1,5-benzothiazepine.
Kanagasabapathy T, Krishnaswamy P, Ramasubbu J. Kanagasabapathy T, et al. Acta Crystallogr C. 2009 Nov;65(Pt 11):o579-82. doi: 10.1107/S0108270109036646. Epub 2009 Oct 17. Acta Crystallogr C. 2009. PMID: 19893240
rac-5-Diphenylacetyl-2,2,4-trimethyl-2,3,4,5-tetrahydro-1,5-benzothiazepine, C(26)H(27)NOS, (I), and rac-5-formyl-2,2,4-trimethyl-2,3,4,5-tetrahydro-1,5-benzothiazepine, C(13)H(17)NOS, (II), are b …
rac-5-Diphenylacetyl-2,2,4-trimethyl-2,3,4,5-tetrahydro-1,5-benzothiazepine, C(26)H(27)NOS, (I), a …
One-Pot Synthesis of 5-Amino-2,5-dihydro-1-benzoxepines: Access to Pharmacologically Active Heterocyclic Scaffolds.
Calder ED, Sharif SA, McGonagle FI, Sutherland A. Calder ED, et al. J Org Chem. 2015 May 1;80(9):4683-96. doi: 10.1021/acs.joc.5b00583. Epub 2015 Apr 13. J Org Chem. 2015. PMID: 25847814 Free article.
Chemoselective reduction and functionalization of these compounds allowed access to a range of pharmacologically active 5-amino-2,3,4,5-tetrahydro-1-benzoxepine scaffolds....
Chemoselective reduction and functionalization of these compounds allowed access to a range of pharmacologically active 5-amino-2, …
Synthesis and Pharmacological Evaluation of Novel 2,3,4,5-tetrahydro[1,3]diazepino[1,2-a]benzimidazole Derivatives as Promising Anxiolytic and Analgesic Agents.
Maltsev DV, Spasov AA, Vassiliev PM, Skripka MO, Miroshnikov MV, Kochetkov AN, Eliseeva NV, Lifanova YV, Kuzmenko TA, Divaeva LN, Morkovnik AS. Maltsev DV, et al. Molecules. 2021 Oct 6;26(19):6049. doi: 10.3390/molecules26196049. Molecules. 2021. PMID: 34641593 Free PMC article.
A number of novel 2,3,4,5-tetrahydro[1,3]diazepino[1,2-a]benzimidazole derivatives 2 were obtained by alkylation mainly in the 1H-tautomeric form of 2,3,4,5-tetrahydro[1,3]diazepino[1,2-a]benzimid …
A number of novel 2,3,4,5-tetrahydro[1,3]diazepino[1,2-a]benzimidazole derivatives 2 were obtained …
Two regioisomers of condensed thioheterocyclic triazine synthesized from 6-phenyl-3-thioxo-2,3,4,5-tetrahydro-1,2,4-triazin-5-one.
Hori A, Ishida Y, Kikuchi T, Miyamoto K, Sakaguchi H. Hori A, et al. Acta Crystallogr C. 2009 Dec;65(Pt 12):o593-7. doi: 10.1107/S0108270109043728. Epub 2009 Nov 7. Acta Crystallogr C. 2009. PMID: 19966438
In the crystal structure of 6-phenyl-3-thioxo-2,3,4,5-tetrahydro-1,2,4-triazin-5-one, C(9)H(7)N(3)OS, (I), the 1,2,4-triazine moieties are connected by face-to-face contacts through two kinds of double hydrogen bonds (N-H...O and N-H...S) …
In the crystal structure of 6-phenyl-3-thioxo-2,3,4,5-tetrahydro-1,2,4-triazin-5-one, C(9)H(7)N(3) …
Synthesis of Bioactive 3,4-Dihydro-2 H-naphtho[2,3- b][1,4]oxazine-5,10-dione and 2,3,4,5-Tetrahydro-1 H-naphtho[2,3- b]azepine-6,11-dione Derivatives via the Copper-Catalyzed Intramolecular Coupling Reaction.
You H, Vegi SR, Lagishetti C, Chen S, Reddy RS, Yang X, Guo J, Wang C, He Y. You H, et al. J Org Chem. 2018 Apr 6;83(7):4119-4130. doi: 10.1021/acs.joc.8b00020. Epub 2018 Mar 21. J Org Chem. 2018. PMID: 29546756
A convenient synthesis of 3,4-dihydro-2 H-naphtho[2,3- b][1,4]oxazine-5,10-diones and 2,3,4,5-tetrahydro-1 H-naphtho[2,3- b]azepine-6,11-diones via the copper-catalyzed intramolecular C-O/C-C coupling reaction is described. ...
A convenient synthesis of 3,4-dihydro-2 H-naphtho[2,3- b][1,4]oxazine-5,10-diones and 2,3,4,5-tetrahydro- …
Metal-free [2 + 1 + 3] Cycloaddition of Trifluoroacetaldehyde N-Sulfonylhydrazones with Hexahydro-1,3,5-triazines Leading to Trifluoromethylated 2,3,4,5-Tetrahydro-1,2,4-triazines.
Fang Z, Jin Q, Wang X, Ning Y. Fang Z, et al. J Org Chem. 2022 Mar 4;87(5):2966-2974. doi: 10.1021/acs.joc.1c02810. Epub 2022 Feb 8. J Org Chem. 2022. PMID: 35133818
This operationally simple protocol provides a general synthesis of diverse trifluoromethylated 2,3,4,5-tetrahydro-1,2,4-triazines in 81-97% yield with a broad substrate scope, including aryl, benzyl, and alkyl hexahydro-1,3,5-triazine....
This operationally simple protocol provides a general synthesis of diverse trifluoromethylated 2,3,4,5-tetrah …
Corrosion Mitigation Performance of N80 Steel in 5% Sulfamic Acid Medium by Applying Novel Tetrahydro-1,2,4-triazines Including Triazene Moieties: Electrochemical and Theoretical Approaches.
Abd El-Lateef HM, Shalabi K, Arab AM, Abdallah YM. Abd El-Lateef HM, et al. ACS Omega. 2022 Jun 24;7(27):23380-23392. doi: 10.1021/acsomega.2c01629. eCollection 2022 Jul 12. ACS Omega. 2022. PMID: 35847306 Free PMC article.
We observed our newly developed tetrahydro-1,2,4-triazines, including triazene moieties (THTA), namely, 6-((1E)-1-((2E)-(4-(((Z)-1-(2,4-diphenyl-2,3,4,5-tetrahydro-1,2,4-triazin-5-yl) ethylidene) triaz-1-en-1-yl)piperazin-1-yl) triaz-2-en …
We observed our newly developed tetrahydro-1,2,4-triazines, including triazene moieties (THTA), namely, 6-((1E)-1-((2E)-(4-(((Z)-1-(2,4-diph …
Inhibition of angiotensin converting enzyme by (R)-3-[(S)-1-carboxy-5-(4-piperidyl)pentyl]amino-4-oxo-2,3,4,5-tetra- hydro-1,5-benzothiazepine-6-acetic acid (CV-5975), a non-sulfhydryl compound.
Inada Y, Tanabe M, Itoh K, Sugihara H, Nishikawa K. Inada Y, et al. Jpn J Pharmacol. 1988 Nov;48(3):323-30. doi: 10.1254/jjp.48.323. Jpn J Pharmacol. 1988. PMID: 2851678 Free article.
CV-5975, (R)-3-[(S)-1-carboxy-5-(4-piperidyl)pentyl]amino-4-oxo- 2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid, was found to inhibit rabbit lung angiotensin converting enzyme (ACE) activity with an IC50 of 3.1 x 10(-9) M and a Ki o …
CV-5975, (R)-3-[(S)-1-carboxy-5-(4-piperidyl)pentyl]amino-4-oxo- 2,3,4,5-tetrahydro-1,5-benzothiaz …
198 results