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Blood. 2010 Jan 21;115(3):510-8. doi: 10.1182/blood-2009-07-232694. Epub 2009 Nov 12.

Foxp1 is an essential transcriptional regulator for the generation of quiescent naive T cells during thymocyte development.

Author information

  • 1Immunology Program and Wistar Vaccine Center, The Wistar Institute, Philadelphia, PA, USA.

Abstract

Proper thymocyte development is required to establish T-cell central tolerance and to generate naive T cells, both of which are essential for T-cell homeostasis and a functional immune system. Here we demonstrate that the loss of transcription factor Foxp1 results in the abnormal development of T cells. Instead of generating naive T cells, Foxp1-deficient single-positive thymocytes acquire an activated phenotype prematurely in the thymus and lead to the generation of peripheral CD4(+) T and CD8(+) T cells that exhibit an activated phenotype and increased apoptosis and readily produce cytokines upon T-cell receptor engagement. These results identify Foxp1 as an essential transcriptional regulator for thymocyte development and the generation of quiescent naive T cells.

PMID:
19965654
[PubMed - indexed for MEDLINE]
PMCID:
PMC2810984
Free PMC Article

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