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Obstet Gynecol. 2009 Dec;114(6):1295-306. doi: 10.1097/AOG.0b013e3181c225c0.

Prenatal exposure to acetaminophen and asthma in children.

Author information

  • 1Center for Perinatal Pediatric and Environmental Epidemiology, Yale School of Public Health, New Haven, Connecticut 06510, USA.

Abstract

OBJECTIVE:

To estimate whether prenatal exposure to acetaminophen is associated with risk of diagnosed asthma and asthma symptoms in children.

METHODS:

The authors prospectively followed 1,505 pregnant women and their children until 6 years (+/-3 months) of life. Acetaminophen use in the first and third trimesters of pregnancy was assessed before 24 weeks of gestation and within 1 month of delivery, and asthma in children was assessed when the child was 6 years old. Adjusted odds ratios (aORs) were derived from logistic regression models controlling for potential confounders.

RESULTS:

Acetaminophen was used by 69% of women during pregnancy. Use of acetaminophen did not significantly increase the risk of asthma (aOR 0.76, 95% confidence interval [CI] 0.53-1.10). Acetaminophen use during both the first and the third trimester was associated with a significantly reduced risk of asthma (aOR 0.59, 95% CI 0.36-0.98). There was no evidence of a dose response, and consumption greater than 10,400 mg (32 tablets) a month did not increase risk (aOR 0.99, 95% CI 0.19-5.30).

CONCLUSION:

Our results suggest that acetaminophen use during pregnancy does not increase risk of asthma in children.

LEVEL OF EVIDENCE:

II.

PMID:
19935033
[PubMed - indexed for MEDLINE]
PMCID:
PMC3237391
Free PMC Article
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