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Org Lett. 2009 Dec 3;11(23):5422-4. doi: 10.1021/ol901997k.

Lodopyridone, a structurally unprecedented alkaloid from a marine actinomycete.

Author information

  • 1Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093-0204, USA.

Abstract

Chemical examination of the secondary metabolites of a marine Saccharomonospora sp., isolated from marine sediments collected at the mouth of the La Jolla Submarine Canyon, yielded the unprecedented alkaloid lodopyridone (1). The low proton-to-carbon ratio of 1 precluded structure elucidation by NMR spectroscopic methods, thus the structure was defined by X-ray crystallography. Lodopyridone is cytotoxic to HCT-116 human colon cancer cells with IC(50) = 3.6 microM.

PMID:
19883103
[PubMed - indexed for MEDLINE]
PMCID:
PMC2820114
Free PMC Article

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