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Exp Neurol. 2010 Jan;221(1):129-35. doi: 10.1016/j.expneurol.2009.10.011. Epub 2009 Oct 22.

Hepatocyte growth factor (HGF) modulates GABAergic inhibition and seizure susceptibility.

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  • 1Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.


Disrupted ontogeny of forebrain inhibitory interneurons leads to neurological disorders, including epilepsy. Adult mice lacking the urokinase plasminogen activator receptor (Plaur) have decreased numbers of neocortical GABAergic interneurons and spontaneous seizures, attributed to a reduction of hepatocyte growth factor/scatter factor (HGF/SF). We report that by increasing endogenous HGF/SF concentration in the postnatal Plaur null mouse brain maintains the interneuron populations in the adult, reverses the seizure behavior and stabilizes the spontaneous electroencephalogram activity. The perinatal intervention provides a pathway to reverse potential birth defects and ameliorate seizures in the adult.

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