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Cancer Invest. 2009 Nov;27(9):942-51. doi: 10.3109/07357900902849632.

Vitamin D and non-Hodgkin lymphoma risk in adults: a review.

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  • 1Department of Community and Preventive Medicine, University of Rochester, Rochester, NY 14642, USA.


Animal and human studies support a protective effect of vitamin D sufficiency related to malignancy by uncovering paracrine and autocrine effects of extra-renal 25-hydroxyvitamin D (25(OH)D) activation including regulation of cell cycle proliferation, apoptosis induction, and increased cell differentiation signaling. Recent epidemiologic studies demonstrate a reduction in non-Hodgkin lymphoma (NHL) risk with increased sunlight exposure. As sunlight is a major vitamin D source, it has been suggested that vitamin D status may mediate this observed association. This review provides a comprehensive discussion of the current epidemiologic evidence with regard to the investigation of an association between vitamin D status and NHL risk.

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