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Cell. 2009 Jun 26;137(7):1177-9. doi: 10.1016/j.cell.2009.06.002.

GABA keeps up an appetite for life.

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  • 1Program on Cell and Neurobiology of Energy Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.

Abstract

In the arcuate nucleus of the hypothalamus, neurons that produce the neuropeptides NPY and AgRP play a vital role in the maintenance of energy homeostasis. In this issue, Wu et al. (2009) show that these neurons modulate feeding behavior in mice by providing GABAergic input to the parabrachial nucleus in the brainstem.

PMID:
19563747
[PubMed - indexed for MEDLINE]
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