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Behav Pharmacol. 2009 Mar;20(2):119-33. doi: 10.1097/FBP.0b013e32832a80ad.

Assessing the validity of current mouse genetic models of obsessive-compulsive disorder.

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  • 1Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois, USA.


Obsessive-compulsive disorder (OCD) is a disorder characterized by unwanted and intrusive thoughts, images, or impulses and/or repetitive behavior. OCD is a major cause of disability; however, the genetic factors and pathophysiological mechanisms underlying this complex, heterogeneous disorder remain largely unknown. During the past decade, a number of putative mouse genetic models of OCD have been developed for the purpose of studying the neural mechanisms underlying this disorder and developing novel treatments. This review presents and evaluates these experimental preparations to date. Models using knockout or transgenic approaches, as well as those examining variation in genetically diverse populations, are evaluated and discussed.

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