Chronic daily headache (CDH) represents a therapeutic challenge for many clinicians. Treatment strategies should be aimed at correctly identifying the presence of CDH. In addition, an effective prophylactic regimen should be initiated; the presence of medication overuse must be addressed, and the offending medication being overused must be discontinued. Aside from analgesic overuse, other modifiable risk factors associated with the development of chronic migraine and CDH must be addressed including obesity and caffeine use and the effective management of comorbid conditions such as depression, anxiety, and sleep-related breathing disorders.