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Nat Rev Mol Cell Biol. 2009 Feb;10(2):116-25. doi: 10.1038/nrm2621.

MicroRNAs: key regulators of stem cells.

Author information

  • 1Yale Stem Cell Center, Yale University School of Medicine, 10 Amistad Street, New Haven, Connecticut 06520-8002, USA.

Abstract

The hallmark of a stem cell is its ability to self-renew and to produce numerous differentiated cells. This unique property is controlled by dynamic interplays between extrinsic signalling, epigenetic, transcriptional and post-transcriptional regulations. Recent research indicates that microRNAs (miRNAs) have an important role in regulating stem cell self-renewal and differentiation by repressing the translation of selected mRNAs in stem cells and differentiating daughter cells. Such a role has been shown in embryonic stem cells, germline stem cells and various somatic tissue stem cells. These findings reveal a new dimension of gene regulation in controlling stem cell fate and behaviour.

PMID:
19165214
[PubMed - indexed for MEDLINE]
PMCID:
PMC4118578
Free PMC Article
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