Format

Send to:

Choose Destination
See comment in PubMed Commons below
Am J Clin Nutr. 2009 Jan;89(1):347-53. doi: 10.3945/ajcn.2008.26722. Epub 2008 Dec 3.

Fruit and vegetable intake and risk of cancer: a prospective cohort study.

Author information

  • 1Yale School of Public Health, New Haven, CT, USA.

Erratum in

  • Am J Clin Nutr. 2010 Oct;92(4):1001.

Abstract

BACKGROUND:

There is probable evidence that some types of fruit and vegetables provide protection against many cancers.

OBJECTIVE:

We hypothesized that fruit and vegetable intakes are inversely related to the incidence of total cancers among women and men aged >50 y.

DESIGN:

We performed a prospective study among the cohort of the National Institutes of Health-AARP Diet and Health Study. We merged the MyPyramid Equivalents Database (version 1.0) with food-frequency-questionnaire data to calculate cup equivalents for fruit and vegetables. From 1995 to 2003, we identified 15,792 and 35,071 cancer cases in 195,229 women and 288,109 men, respectively. We used Cox proportional hazards models to estimate multivariate relative risks (RRs) and 95% CIs associated with the highest compared with the lowest quintile (Q) of fruit and vegetable intakes.

RESULTS:

Fruit intake was not associated with the risk of total cancer among women (RR(Q5 vs Q1) = 0.99; 95% CI: 0.94, 1.05; P trend = 0.059) or men (RR(Q5 vs Q1) = 0.98; 95% CI: 0.95, 1.02; P for trend = 0.17). Vegetable intake was not associated with risk of total cancer among women (RR(Q5 vs Q1) = 1.04; 95% CI: 0.98, 1.09; P for trend = 0.084), but was associated with a significant decrease in risk in men (RR(Q5 vs Q1) = 0.94; 95% CI: 0.91, 0.97; P trend = 0.004). This significant finding among men was no longer evident when we limited the analysis to men who never smoked (RR(Q5 vs Q1) = 0.97; 95% CI: 0.91, 1.04; P for trend = 0.474).

CONCLUSIONS:

Intake of fruit and vegetables was generally unrelated to total cancer incidence in this cohort. Residual confounding by smoking is a likely explanation for the observed inverse association with vegetable intake among men.

PMID:
19056579
[PubMed - indexed for MEDLINE]
PMCID:
PMC2647712
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk