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J Exp Med. 2008 Nov 24;205(12):2699-701. doi: 10.1084/jem.20082429. Epub 2008 Nov 17.

TIMs: central regulators of immune responses.

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  • 1Center for Neurological Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Abstract

Exhaustion of T cell responses during chronic viral infections has been observed in both mouse and man and has been attributed to up-regulation of PD-1 on the surface of exhausted T cells. In patients with chronic human HIV infection, T cell exhaustion leads to opportunistic infections associated with AIDS. However, not all the exhausted T cells express PD-1, suggesting that other molecules may be involved in the phenotype. A new study now demonstrates a central role for T cell immunoglobulin and mucin domain-containing protein-3 (TIM-3) in T cell exhaustion during chronic HIV infection and suggests that TIM-3 may be a novel therapeutic target in chronic viral diseases.

PMID:
19015312
[PubMed - indexed for MEDLINE]
PMCID:
PMC2585854
Free PMC Article
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