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Diabetes Care. 2009 Jan;32(1):45-7. doi: 10.2337/dc08-0808. Epub 2008 Oct 7.

Effect of a successful intensive lifestyle program on insulin sensitivity and glucose tolerance in obese youth.

Author information

  • 1Department of Pediatrics, Yale University, New Haven, Connecticut, USA. melissa.m.shaw@yale.edu

Abstract

OBJECTIVE:

To evaluate the impact on glucose metabolism of a lifestyle program (the Yale Bright Bodies Program) for obese children.

RESEARCH DESIGN AND METHODS:

Thirteen Bright Bodies and ten clinic-care control subjects who were part of a large randomized clinical trial had 75-g oral glucose tolerance tests at the beginning and end of the 12-month study.

RESULTS:

Bright Bodies subjects had significantly greater decreases in weight, BMI, and body fat than clinic-care subjects, and the Bright Body subjects' changes in body composition were accompanied by marked improvements in insulin sensitivity (P = 0.009) and glucose tolerance (P = 0.04).

CONCLUSIONS:

An intensive lifestyle program that successfully reduces body weight and body fat can markedly improve insulin sensitivity and glucose metabolism in obese youth.

PMID:
18840769
[PubMed - indexed for MEDLINE]
PMCID:
PMC2606827
Free PMC Article
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