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Neuron. 2008 Aug 14;59(3):349-51. doi: 10.1016/j.neuron.2008.07.028.

Keeping 'trk' of antidepressant actions.

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  • 1Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06508, USA.


Despite growing evidence that increased brain-derived neurotrophic factor (BDNF) and hippocampal adult neurogenesis are necessary for the behavioral actions of antidepressants in rodents, the cellular mechanisms involved in these effects are still unknown. Li et al. in this issue of Neuron demonstrate that the presence of TrkB, the high-affinity receptor for BDNF, in hippocampal neural progenitor cells is required for the neurogenic and behavioral actions of antidepressant treatments.

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