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Dev Cell. 2008 Aug;15(2):179-81. doi: 10.1016/j.devcel.2008.07.016.

A descent into the nuage: the maelstrom of transposon control.

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  • 1Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Abstract

In this issue of Developmental Cell, Soper et al. (2008) report that the mammalian MAELSTROM (MAEL) protein is critical for transposon silencing in the male germline. Loss of MAEL is associated with meiotic failure and DNA damage, suggesting that efficient transposable element restraining mechanisms must be in place for the preservation of germline integrity.

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PMID:
18694557
[PubMed - indexed for MEDLINE]
PMCID:
PMC2867346
Free PMC Article
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