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J Cereb Blood Flow Metab. 2008 Dec;28(12):1892-7. doi: 10.1038/jcbfm.2008.78. Epub 2008 Jul 16.

Chronic riluzole treatment increases glucose metabolism in rat prefrontal cortex and hippocampus.

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  • 1Department of Diagnostic Radiology, Magnetic Resonance Research Center, Yale University School of Medicine, New Haven, Connecticut, USA. golam.chowdhury@yale.edu

Abstract

Riluzole is believed to modulate glutamatergic function by reducing glutamate release and facilitating astroglial uptake. We measured (13)C labeling in metabolites in prefrontal cortex and hippocampus during a 10 mins infusion of [1-(13)C]glucose in urethane anesthetized rats treated with riluzole (21 days, 4 mg/kg per day, i.p.) or saline. Total and (13)C concentrations of metabolites were determined in extracts using (1)H-[(13)C] NMR spectroscopy. In prefrontal cortex (P<0.05) and hippocampus (P<0.05) riluzole increased (13)C labeling over saline in glutamate-C4 (to 112% and 130%), GABA-C2 (to 142% and 171%), and glutamine-C4 (to 118% and 233%) without affecting total metabolite levels (P>0.2). Our findings indicate that contrary to expectation chronic riluzole enhanced glucose oxidative metabolism and glutamate/glutamine cycling.

PMID:
18628780
[PubMed - indexed for MEDLINE]
PMCID:
PMC2739056
Free PMC Article
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