Anaphylaxis to vecuronium: the use of basophil CD63 expression as a possible screening tool to identify a safe alternative

Potteth S Sudheer; Ian R Appadurai

doi:10.1016/j.jclinane.2007.03.011

Anaphylaxis to vecuronium: the use of basophil CD63 expression as a possible screening tool to identify a safe alternative

J Clin Anesth. 2007 Nov;19(7):555-7. doi: 10.1016/j.jclinane.2007.03.011.

Authors

Potteth S Sudheer¹, Ian R Appadurai

Affiliation

¹ Department of Anaesthetics, University Hospital of Wales, Heath Park, Cardiff, Wales, UK. sudheerps@cf.ac.uk

PMID: 18063215
DOI: 10.1016/j.jclinane.2007.03.011

Abstract

A 29-year-old woman with a history of anaphylaxis during anesthesia required diagnostic laparoscopic surgery for investigation of infertility. Previous laboratory investigations suggested that she had reacted to vecuronium, but she also had a specific IgE antibody to succinylcholine. The use of the basophil activation marker CD63 as a screening tool in selecting a safe muscle relaxant is presented.

Publication types

Case Reports

MeSH terms

Adult
Anaphylaxis / etiology*
Anesthesia, General
Antigens, CD / genetics*
Antigens, CD / metabolism
Atracurium / analogs & derivatives
Basophils / metabolism*
Cross Reactions
Diagnostic Techniques, Surgical
Female
Gene Expression
Genetic Testing
Humans
Infertility, Female / diagnosis
Neuromuscular Nondepolarizing Agents / adverse effects*
Platelet Membrane Glycoproteins / genetics*
Platelet Membrane Glycoproteins / metabolism
Succinylcholine / adverse effects
Tetraspanin 30
Vecuronium Bromide / adverse effects*

Substances

Antigens, CD
CD63 protein, human
Neuromuscular Nondepolarizing Agents
Platelet Membrane Glycoproteins
Tetraspanin 30
Atracurium
Vecuronium Bromide
Succinylcholine
cisatracurium