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AAPS J. 2007 Jun 8;9(2):E171-80.

Nanosystems for simultaneous imaging and drug delivery to T cells.

Author information

  • 1Department of Biomedical Engineering, Yale University, New Haven, CT 06511, USA. Tarek.fahmy@yale.edu

Abstract

The T-cell response defines the pathogenesis of many common chronic disease states, including diabetes, rheumatoid arthritis, and transplant rejection. Therefore, a diagnostic strategy that visualizes this response can potentially lead to early therapeutic intervention, avoiding catastrophic organ failure or prolonged sickness. In addition, the means to deliver a drug dose to those cells in situ with the same specificity used to image those cells would provide for a powerful therapeutic alternative for many disease states involving T cells. In this report, we review emerging nanosystems that can be used for simultaneous tracking and drug delivery to those cells. Because of their versatility, these systems--which combine specific receptor targeting with an imaging agent and drug delivery--are suited to both basic science and applications, from developing therapeutic strategies for autoimmune and alloimmune diseases, to noninvasive tracking of pathogenic T-cell migration.

PMID:
17614359
[PubMed - indexed for MEDLINE]
PMCID:
PMC2751406
Free PMC Article
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