Abstract
Artemisinin compounds inhibit in vitro growth of cultured Trypanosoma cruzi and Trypanosoma brucei rhodesiense at concentrations in the low micromolar range. Artemisinin also inhibits calcium-dependent ATPase activity in T. cruzi membranes, suggesting a mode of action via membrane pumps. Artemisinins merit further investigation as chemotherapeutic options for these pathogens.
MeSH terms
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Animals
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Anti-Infective Agents / pharmacology*
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Artemisinins / pharmacology*
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Calcium-Transporting ATPases / antagonists & inhibitors
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Parasitic Sensitivity Tests
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Sesquiterpenes / pharmacology*
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Trypanosoma brucei rhodesiense / drug effects*
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Trypanosoma brucei rhodesiense / growth & development
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Trypanosoma cruzi / drug effects*
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Trypanosoma cruzi / growth & development
Substances
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Anti-Infective Agents
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Artemisinins
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Sesquiterpenes
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artemisinin
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Calcium-Transporting ATPases