Send to:

Choose Destination
See comment in PubMed Commons below
Virology. 2007 Jun 20;363(1):113-23. Epub 2007 Feb 21.

Mapping and restriction of a dominant viral CD4+ T cell core epitope by both MHC class I and MHC class II.

Author information

  • 1Barbara Davis Center, University of Colorado at Denver and Health Sciences Center, 12801 East 17th Avenue, Aurora CO, USA.


Virus-specific CD4(+) T cells contribute to effective virus control through a multiplicity of mechanisms including direct effector functions as well as "help" for B cell and CD8(+) T cell responses. Here, we have used the lymphocytic choriomeningitis virus (LCMV) system to assess the minimal constraints of a dominant antiviral CD4(+) T cell response. We report that the core epitope derived from the LCMV glycoprotein (GP) is 11 amino acids in length and provides optimal recognition by epitope-specific CD4(+) T cells. Surprisingly, this epitope is also recognized by LCMV-specific CD8(+) T cells and thus constitutes a unique viral determinant with dual MHC class I- and II-restriction.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk