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Cell Metab. 2007 Feb;5(2):151-6.

Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis.

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  • 1Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA.

Abstract

Recent studies have demonstrated a strong relationship between aging-associated reductions in mitochondrial function, dysregulated intracellular lipid metabolism, and insulin resistance. Given the important role of the AMP-activated protein kinase (AMPK) in the regulation of fat oxidation and mitochondrial biogenesis, we examined AMPK activity in young and old rats and found that acute stimulation of AMPK-alpha(2) activity by 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) and exercise was blunted in skeletal muscle of old rats. Furthermore, mitochondrial biogenesis in response to chronic activation of AMPK with beta-guanidinopropionic acid (beta-GPA) feeding was also diminished in old rats. These results suggest that aging-associated reductions in AMPK activity may be an important contributing factor in the reduced mitochondrial function and dysregulated intracellular lipid metabolism associated with aging.

PMID:
17276357
[PubMed - indexed for MEDLINE]
PMCID:
PMC1885964
Free PMC Article
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