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Biol Blood Marrow Transplant. 2007 Jan;13(1 Suppl 1):2-10.

Transplantation's greatest challenges: advances in chronic graft-versus-host disease.

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  • 1Department of Medical Oncology, Yale University School of Medicine, New Haven, Connecticut, USA.


Clinical research into chronic graft-versus-host disease (GVHD) lags behind that in other areas in the field. Interest in chronic GVHD has increased significantly in recent years for various reasons, including advances in biotechnology, a perceived increase in the incidence of chronic GVHD, and decreased regimen-related mortality, resulting in a new emphasis on quality of life and absence of disability as endpoints of major significance in transplantation survivors. In this overview, we address 3 key areas related to chronic GVHD that hold the highest promise for major advances in the near future: pathobiology, response criteria, and therapy.

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