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Immunol Today. 1991 Aug;12(8):277-82.

T-cell recognition of myelin basic protein.

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  • 1Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA.


Multiple sclerosis is a chronic inflammatory disease of the central nervous system which has been hypothesized to be autoimmune in nature. To test whether this is the case, Kai Wucherpfennig and colleagues have developed a set of criteria that must be met to satisfy the hypothesis. Here, they present these criteria and assess the extent to which studies to date satisfy them.

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