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Pediatr Blood Cancer. 2008 Feb;50(2):354-6.

Pinch-off syndrome in patients with sickle cell disease receiving erythrocytapheresis.

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  • 1Department of Pediatric Hematology, The Children's Hospital and the University of Colorado at Denver Health Sciences Center, Denver, Colorado, USA.


A 6-year-old female with homozygous sickle cell disease had a central venous access device (CVAD) placed to facilitate chronic erythrocytapheresis. Erythrocytapheresis was ineffective due to the rare pinch-off syndrome causing communication between the dual lumen tubing. Awareness of and monitoring for the pinch-off syndrome is indicated in people with sickle cell disease and a CVAD for chronic erythrocytapheresis.

(c) 2007 Wiley-Liss, Inc.

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