Brain natriuretic peptide as marker of myocardial iron load in beta-thalassemia

Int J Cardiol. 2007 Jun 12;118(3):408-9. doi: 10.1016/j.ijcard.2006.07.052. Epub 2006 Oct 12.

Abstract

Cardiomyopathy due to iron overload represents a frequent life-limiting complication in patients with beta-thalassemia major. We have conducted a study which proved that brain natriuretic peptide plasma levels have high sensitivity and negative predictive value in detecting cardiac hemosiderosis.

Publication types

  • Comparative Study
  • Letter

MeSH terms

  • Adult
  • Biomarkers / blood
  • Blood Transfusion / methods
  • Cardiomyopathies / diagnosis*
  • Cardiomyopathies / etiology
  • Cohort Studies
  • Female
  • Hemosiderosis / diagnosis
  • Humans
  • Iron Overload / diagnosis*
  • Male
  • Natriuretic Peptide, Brain / blood*
  • Natriuretic Peptide, Brain / metabolism
  • Predictive Value of Tests
  • Probability
  • Prognosis
  • Sensitivity and Specificity
  • Severity of Illness Index
  • beta-Thalassemia / complications*
  • beta-Thalassemia / diagnosis
  • beta-Thalassemia / therapy

Substances

  • Biomarkers
  • Natriuretic Peptide, Brain