Abstract
An ethanol extract of the Peruvian plant Clavija procera, a member of the rare Theophrastaceae family, was fractionated using a colorimetric bioassay-guided protocol against Mycobacterium tuberculosis (MTB), yielding the oleanane triterpenoid aegicerin (1) as the active constituent. Its MIC values ranged between 1.6 and 3.12 microg/mL against 37 different sensitive and resistant MTB strains (1 H37Rv, 21 susceptible clinical isolates, 2 INH-resistant clinical isolates, and 13 MDR clinical isolates).
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Antitubercular Agents* / chemistry
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Antitubercular Agents* / isolation & purification
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Antitubercular Agents* / pharmacology
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Chlorocebus aethiops
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Drug Resistance, Multiple, Bacterial
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Microbial Sensitivity Tests
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Mycobacterium tuberculosis / drug effects*
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Oleanolic Acid / analogs & derivatives*
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Oleanolic Acid / chemistry
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Oleanolic Acid / isolation & purification
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Oleanolic Acid / pharmacology
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Plants, Medicinal / chemistry*
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Triterpenes* / chemistry
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Triterpenes* / isolation & purification
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Triterpenes* / pharmacology
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Vero Cells
Substances
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Antitubercular Agents
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Triterpenes
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aegicerin
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oleanane
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Oleanolic Acid