Abstract
Using HPLC/microtiter-plate-based generation of activity profiles the extract of a marine alga-derived fungus, identified as Gliocladium sp., was shown to contain the known strongly cytotoxic metabolite 4-keto-clonostachydiol (1) and also clonostachydiol (2) as well as gliotide (3), a new cyclodepsipeptide containing several D-amino acids. The absolute configuration of 1 was elucidated by reduction to 2, and two further oxidized derivatives of clonostachydiol (5, 6) were prepared and evaluated for biological activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Chromatography, High Pressure Liquid
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Depsipeptides / chemistry
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Depsipeptides / isolation & purification*
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Depsipeptides / pharmacology
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Drug Screening Assays, Antitumor
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Eukaryota
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Gliocladium / chemistry*
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Lactones / chemistry
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Lactones / isolation & purification*
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Lactones / pharmacology
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Leukemia P388
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Marine Biology
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Mice
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Molecular Structure
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New Zealand
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Oxidation-Reduction
Substances
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4-keto-clonostachydiol
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Antineoplastic Agents
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Depsipeptides
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Lactones
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gliotide
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clonostachydiol