Format

Send to:

Choose Destination
See comment in PubMed Commons below
Cell Cycle. 2006 Apr;5(7):722-8. Epub 2006 Apr 1.

Adult neurogenesis: basic concepts of signaling.

Author information

  • 1Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520-8082, USA. angelique.bordey@yale.edu

Abstract

Findings over the past decades demonstrating persistent neurogenesis in the adult brain have challenged the view of a fixed circuitry in normally functioning brain and raised hopes for self-renewal following brain injury. In addition to providing insights for repair, studying adult neurogenesis may improve our understanding of embryonic development assuming that fundamental mechanisms are similar. It is argued here, using examples of cell:cell communication, that parallels can be drawn between adult and embryonic neurogenesis. Paradoxically, cell:cell communication in neurogenic regions resembles that in a mature neuroglial network. This suggests that differences in the integrative properties of cells and the extracellular matrix molecules may constitute a neurogenic environment or "niche". While reasons for persistent adult neurogenesis in humans remains obscure, recent findings regarding the environmental and activity-driven control of neurogenesis reinforce the original concept of a role for neurogenesis in motor memory formation and refinement of information processing.

PMID:
16582623
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Landes Bioscience
    Loading ...
    Write to the Help Desk